Endeavor BioMedicines is a clinical-stage biotechnology company developing medicines with the potential to deliver transformational clinical benefits to patients with life-threatening diseases. Endeavor’s lead investigational candidate, ENV-101, is an inhibitor of the Hedgehog (Hh) signaling pathway in clinical development for the treatment of fibrotic lung disease, including idiopathic pulmonary fibrosis (IPF). The company’s second investigational candidate, ENV-501 is a human epidermal growth factor 3 (HER3)-targeted antibody-drug conjugate (ADC) for the treatment of HER3-positive solid tumors.

OUR SCIENCE

Our approach is embodied in our pipeline of potential therapies that precisely target the root cause of disease to deliver transformational clinical benefits and the potential to change treatment expectations.
Our leadership team has deep experience developing drug candidates into leading medicines that make a meaningful difference in patients’ lives.

OUR LEADERSHIP

OUR CULTURE

We have a vibrant and passionate culture that reflects our shared mission to deliver new therapeutic options for patients with life-threatening diseases.

LATEST NEWS

First Patient Dosed in Endeavor BioMedicines’ Phase 2b WHISTLE-PF Trial Evaluating ENV-101 for the Treatment of Idiopathic Pulmonary Fibrosis

- ENV-101, a novel investigational Hedgehog signaling pathway inhibitor, has demonstrated clinical potential to improve lung function and total lung capacity, and reverse multiple key quantitative measures of lung fibrosis SAN DIEGO – November 20, 2024 – Endeavor BioMedicines, a clinical-stage biotechnology company developing medicines with the potential to deliver transformational...

New Phase 2a Clinical Trial Results Demonstrate Endeavor BioMedicines’ ENV-101 Improved Lung Function and Reversed Key Measures of Lung Fibrosis in Patients With Idiopathic Pulmonary Fibrosis

Data presented for the first time today during late-breaking oral session at the American Thoracic Society 2024 International Conference Patients who received ENV-101 experienced statistically significant improvements in lung function and total lung capacity, and reversal of multiple key quantitative measures of lung fibrosis through 12 weeks of treatment Findings reinforce potential...

Purple Lungs Image

Fibrotic Lung Disease

ENV-101 has the potential to be the first-ever disease-modifying therapy for pulmonary fibrosis, including IPF.

Blue Brain Diagram

Oncology

ENV-501 is an optimized next-generation anti-HER3 antibody-drug conjugate with the potential to treat multiple tumor types.

Transforming Treatment Expectations

At Endeavor BioMedicines, we’re striving to develop groundbreaking medicines that go beyond slowing disease progression to reverse the trajectory of relentless diseases.

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