Join Endeavor BioMedicines at the American Thoracic Society 2025 (ATS 2025) International Conference in San Francisco!
Join us to learn more about Endeavor BioMedicines, our lead investigational candidate, ENV-101, and our ongoing WHISTLE-PF global clinical trial.
Attend Our ENV-101 Poster Presentations
ENV-101 is a novel investigational Hedgehog signaling pathway inhibitor in development for fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Endeavor abstracts being presented at ATS 2025 will highlight new results from the Phase 2a placebo-controlled study of ENV-101 in patients with IPF, as well as the study design of the WHISTLE-PF Phase 2b, multi-center, randomized, double-blind, placebo-controlled trial of ENV-101 in patients with IPF.
Deep Learning-based Disease Severity Biomarkers on CT; Posthoc Analysis in a Phase 2a Placebo-controlled Study of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis
Abstract Session: C23 – On The Horizon: Imaging and Molecular Biomarkers in Fibrotic ILD
Poster Board: #P863
Simon Walsh, M.D., Ph.D., Thoracic Radiologist, Qureight Ltd.
Date: May 20, 2025
Time: 9:15 a.m. – 11:15 a.m. PT
Location: Room 2002/2004 (West Building, Level 2), Moscone Center
WHISTLE-PF: Study Design Of A Phase 2b, Multi-center, Randomized, Double-blind, Controlled Trial of ENV-101 (Taladegib) In Patients With Idiopathic Pulmonary Fibrosis
Abstract Session: A74 – Fibrotic Lung Disease Revisited
Poster Board: #610
Toby M. Maher, M.D., Ph.D., Professor of Medicine and Director of Interstitial Lung Disease at Keck School of Medicine, University of Southern California, Los Angeles
Date: May 18, 2025
Time: 11:30 a.m. – 1:15 p.m. PT
Location: Area G, Hall F (North Building, Exhibition Level), Moscone Center
Visit Booth 2031 to Learn More About Our WHISTLE-PF Trial
In 2024, Endeavor BioMedicines initiated patient enrollment in the WHISTLE-PF* clinical trial, a global Phase 2b trial evaluating the therapeutic potential of ENV-101 in individuals with IPF. Endeavor BioMedicines intends to conduct the trial globally.
MEET OUR LEADERSHIP TEAM
Members of Endeavor BioMedicines’ leadership team will be on site at ATS 2025:
John Hood, PhD
Co-Founder & Chief Executive Officer
Dr. Hood is Co-Founder, Chief Executive Officer (CEO) and Executive Chairman of Endeavor BioMedicines. A veteran of the California life sciences community, Dr. Hood has founded and led several successful biotechnology companies throughout his 20-year career. He previously served as the Founder and CEO of Impact Biomedicines (now owned by Bristol Myers Squibb), the company that developed fedratinib, which is now approved worldwide for the treatment of myelofibrosis. Dr. Hood began his career in 2001 as Director of Research at TargeGen, where he co-discovered fedratinib and led a team identifying small molecule therapeutics for the treatment of cancer and eye disease. He is an inventor on 100+ patents and the author of 50+ scientific articles. Dr. Hood earned his PhD in Medical Physiology and a Bachelor of Science in Biochemistry from Texas A&M University.
Miguel de los Rios, PhD
Co-Founder & Chief Scientific Officer
Dr. de los Rios is Co-Founder and Chief Scientific Officer (CSO) of Endeavor BioMedicines. An entrepreneur focused on developing novel therapeutics to satisfy unmet needs in human medicine, he has more than 20 years of experience in the pharmaceutical industry. Prior to co-founding Endeavor, Dr. de los Rios was Founder and Chief Executive Officer at Rift Biotherapeutics, a therapeutic antibody company focused on cancers, as well as Vice President of Research and Development at Sevion Therapeutics (formerly Fabrus, Inc.), a clinical-stage therapeutics company focused on oncology and autoimmune disorders. In 2003 while working to complete his PhD, he founded Chimeros, Inc., a venture-backed biologics therapeutic company. He is the lead author or inventor on 50+ publications, patents and patent applications. Dr. de los Rios earned his PhD in Biophysical Chemistry and a Bachelor of Science in Cell Biology, both at the University of California, Santa Barbara.
Vishaal Turakhia
Chief Financial Officer
Mr. Turakhia is Chief Financial Officer (CFO) at Endeavor BioMedicines and has 15 years of investment banking experience. Prior to joining Endeavor, he served as a Managing Director in the Healthcare Investment Banking Group at Piper Sandler, where he advised management teams and boards of biopharma companies on a range of financing and strategic transactions. Prior to Piper Sandler, Mr. Turakhia served as Vice President in the Healthcare Investment Banking Groups at Bank of America Merrill Lynch and RBC Capital Markets, and an Equity Research Analyst in the Healthcare Group at Goldman Sachs, where he covered SMID-cap biopharma companies. During his career, he has executed more than 80 transactions, including over $50 billion in equity and debt financings and M&A. Mr. Turakhia earned a Bachelor of Science in Finance and Accounting from Ithaca College, and a Master of Science in Finance from the Simon School of Business at the University of Rochester.
Lisa Lancaster, MD
Chief Medical Officer
Dr. Lancaster is Chief Medical Officer at Endeavor BioMedicines. She is a Professor of Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine within the Department of Medicine at Vanderbilt University Medical Center. Dr. Lancaster joined the Vanderbilt faculty following completion of her fellowship and was named the Interstitial Lung Disease (ILD) Program Director in 2000. Since then, the Vanderbilt IPF and ILD Research Program has completed more than 80 clinical trials and registries caring for patients in a seven-state referral base and nationally. Vanderbilt’s ILD Center was a founding member of the former National Heart, Lung, and Blood Institute-sponsored IPF Clinical Research Network (IPFnet). Dr. Lancaster has served on multiple ILD steering committees and advisory boards and has authored or coauthored over 100 ILD-related publications. This included serving as a principal investigator for pivotal clinical trials evaluating the two currently approved idiopathic pulmonary fibrosis therapies. Her national leadership roles have included membership in the Steering Committee for the Diffuse Lung Disease Network of the American College of Chest Physicians and the Steering Committee for the Pulmonary Fibrosis Foundation Registry. Dr. Lancaster earned her Bachelor of Science in Biochemistry at The University of Georgia and her MD at the Medical College of Georgia.
John Huetsch, MD
Executive Medical Director
Dr. Huetsch is Executive Medical Director at Endeavor BioMedicines. He is a pulmonary and critical care physician with experience in drug development and academic medicine. Prior to joining Endeavor, he worked in respiratory drug development at Arrowhead Pharmaceuticals. Prior to working in industry, he was an Assistant Professor at Johns Hopkins School of Medicine, where he also completed his fellowship training. He earned his MD at Washington University School of Medicine and his Bachelor of Arts at Harvard University.
Anita DiFrancesco
Senior Vice President, Clinical Operations
Ms. DiFrancesco is Senior Vice President of Clinical Operations at Endeavor BioMedicines. Over her 25 years in the biotech industry she has designed and managed numerous clinical trials from Phase 1 to Phase 3 in therapeutic areas including oncology, pulmonology, musculoskeletal disorders and pain. Ms. DiFrancesco previously served as Vice President of Clinical Operations at Samumed, LLC, and served as a team member at Huya Bioscience, Cypress Bioscience and Chiron Corporation. She earned her Bachelor of Science from Georgetown University.
Randy Adams
Senior Vice President, Strategic Marketing & Communications
Mr. Adams is Senior Vice President of Strategic Marketing and Communications at Endeavor BioMedicines. Prior to joining Endeavor, he was a consultant supporting multiple clinical-stage biotech companies in the areas of strategic marketing and communications. Mr. Adams’ extensive commercial leadership experience includes serving as Vice President of Commercial at Equillium, where he led strategic planning related to the company’s lead drug candidate; Senior Vice President of Commercial at Impact Biomedicines, where he led commercial readiness activities to support the launch of fedratinib (now owned by Bristol Myers Squibb) for the treatment of myelofibrosis; and Executive Vice President and a founding partner at Carling Communications (now owned by Avalere), where he was instrumental in building a global strategic consulting and medical communications agency. Additionally, he previously served as Director of Marketing at Allergan, where he was responsible for leading a $1 billion dry eye portfolio and was instrumental in the launch and successful commercialization of RESTASIS®. Mr. Adams earned a Bachelor of Arts in Business Administration from Georgia College & State University.
Hutch Humphreys
Vice President, Regulatory Affairs
Mr. Humphreys is Vice President of Regulatory Affairs at Endeavor BioMedicines. He is an experienced regulatory professional with over 15 years of increasing responsibility for programs in all phases of product development, from pre-IND to NDA submission and post-approval lifecycle management. Mr. Humphreys served in expanding regulatory leadership roles at Amylin Pharmaceuticals, Therapeutics, Inc., Samumed, LLC and Intercept Pharmaceuticals. He currently serves as an adjunct faculty member at the Keck Graduate Institute (KGI) in Claremont, CA, teaching a course on current issues in regulatory affairs. Mr. Humphreys earned a Bachelor of Science in Chemical Engineering at the University of Kansas. After college, he spent five years as a nuclear-trained submarine officer in the US Navy, serving onboard the USS Helena, homeported in Pearl Harbor, HI, and San Diego, CA. Following military service, he attended KGI, earning a Master of Bioscience degree prior to entering the pharmaceutical industry.