Endeavor

Miguel de los Rios is an entrepreneur focused on developing novel therapeutics to satisfy unmet needs in human medicine. Prior to Endeavor, he was Founder and CEO at Rift Biotherapeutics, a therapeutic antibody company focused on cancers. Prior to that Miguel served as Vice President of Research and Development at Sevion Therapeutics (formerly Fabrus, Inc.), a clinical stage therapeutics company focused in oncology and autoimmune disorders. Miguel founded Chimeros, Inc., a venture-backed biologics therapeutic company in 2003 while working to complete his PhD. He is lead author or inventor on 50+ publications, patents and patent applications. He received his PhD in Biophysical Chemistry and a B.S. in Cell Biology, both at UC Santa Barbara.

Prior to joining Endeavor Biomedicines, Dr. Pendyala was leading the clinical development at BridgeBio focusing on rare diseases. He is a physician-scientist with over 20 years of experience in clinical research, translational sciences and academic medicine. He has a strong background in inflammation, immunology and oncology therapeutic areas. Prior to BridgeBio, he was at Theravance, Merck, Roche/Genentech and led the development of a number of molecules from early/late-stage clinical trials to regulatory approval. He was involved in multiple NDA filings with approvals and in partnered drug development programs. He has a passion for developing new medicines that make a difference in patients’ lives.

Dr. KC is an experienced chemist who has over two decades of experience in drug discovery and CMC with a proven track record of successfully leading medicinal chemistry and CMC projects in every stage of drug discovery and development processes spanning from HTS to process validation and cGMP manufacturing of registration/PPQ batches of drug substance to support approval and post approval commercialization. Previously, Dr. KC was the Vice President of Chemistry at Samumed LLC where he played a key role in discovering and advancing seven NCEs to the clinic, and led CMC operational and strategic activities that included process development and cGMP manufacturing of drug substances to support phase 1-3 clinical trials of seven NCEs for eight different indications. At Samumed, Dr. KC successfully oversaw the design and execution of PPQ enabling multifunctional projects and PPQ campaign of Lorecivivint drug substance. Prior to Samumed, Dr. KC was the Associate Director of Chemistry at Avanir Pharmaceuticals, where he led a team of medicinal chemists working in drug discovery of various therapeutic areas. His team at Avanir discovered two NCEs that entered into the clinic and delivered two projects that were successfully out-licensed to Novartis and AstraZeneca. Dr. KC is an author of 21 peer reviewed scientific publications and inventor on more than 400 pending and issued patents. Dr. KC received his Ph.D. in Medicinal Chemistry from the University of Regensburg, Germany and M.Sc. in Organic Chemistry from Tribhuvan University, Nepal.

Ms. Tobal has over 25 years of industry experience in the life sciences with a career spanning research, business development, corporate venture capital, alliance management, and organizational culture. She most recently served in business development and alliance management for Everest Medicines and held similar roles at La Jolla Pharmaceutical Company and The Scripps Research Institute. Previously, she worked in business development and corporate venture capital at Amgen. She has enjoyed her roles at every stage of the drug development process and is passionate about working with motivated scientists and great teams to develop therapeutics that bring health to patients.
Ms. Tobal received her B.Sc from the University of California: Santa Cruz; her M.Sc in Marine Biology from the Scripps Institution of Oceanography at the University of California: San Diego and an MBA from the Robert H. Smith School of Business at the University of Maryland.