Pipeline

Endeavor

to Develop Leading Medicines

Pipeline

We are focused on developing transformative medicines by targeting the underlying genetic and cellular causes of disease with best-in-class agents. At Endeavor, we will continue to build and advance our pipeline as we acquire additional assets that show promise in improving patient lives.

Program

Preclinical

Phase 1

Phase 2

Phase 3

ENV-101

Oncology
Hedgehog Inhibitor
Phase 2

ENV-101

IPF
Hedgehog Inhibitor
Phase 2

ENV-101

ENV-101 is a small molecule Hedgehog signaling inhibitor that has demonstrated significant clinical efficacy and safety. We are developing ENV-101 as a precision therapy in multiple types of cancer, as well as in idiopathic pulmonary fibrosis (IPF) – where the Hedgehog pathway is implicated as a driver of the disease.

The clinical effects of ENV-101 have been evaluated in nearly 200 people. Six completed studies have characterized the pharmaceutical properties, including PK/PD in patients with advanced solid tumors and demonstrated a superior safety profile compared to similar therapeutics in this class. Across studies enrolling advanced cancer patients, responses were observed at all doses and in multiple tumor types.

ENV-ONC-101

We are developing ENV-101 for patients with tumor mutations in the Hedgehog pathway, which affect approximately 2% of all cancers. Mutations in this pathway can aberrantly activate downstream signaling resulting in proliferation, survival and metastasis of cancer cells. ENV-101 potently and safely inhibits the activity of the Hedgehog pathway which may have a significant benefit on the lives of cancer patients with these mutations.

We are currently enrolling for this trial.

For more information on our trial (NCT05199584): A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations.

ENV-IPF-101

We are developing ENV-101 for patients with idiopathic pulmonary fibrosis (IPF), that has the potential to revolutionize the current standard of care. IPF is characterized by progressive lung scarring and reduction in lung volume. Pathologically, it is a wound that won’t heal.

We are currently enrolling for this trial.

For more information on our trial (NCT04968574): A Study Evaluating the Safety and Efficacy of ENV-101 in Subjects With Idiopathic Pulmonary Fibrosis (IPF).

For more information about our clinical trials please contact us at:

Expanded Access

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